MEG Analysis with Spatial Filtered Reconstruction

Magnetoencephalography (MEG) is a method to measure a magnetic field generated by electrical neural activity in a brain, and it plays increasingly important role in clinical diagnoses and neurophysiological studies. However, in MEG analysis, the estimation of the brain activity, of the electric current density distribution in a brain which is represented by current dipoles, is problematic. A spatial filter and subsequent reconstruction of the current density distribution estimated by the spatial filter (spatial filtered reconstruction: SFR) are proposed. The spatial filter is designed to be used without prior or temporal information. The proposed spatial filter ensures that it concentrates the current distribution around the activated sources in the conductor. The current distribution estimated by the spatial filter is reconstructed by multiple linear regression. Redundant current dipoles are eliminated, and the current distribution is optimized in the sense of the Mallows Cp statistic. Numerical studies are demonstrated and show successful estimation by SFR in multiple-dipole cases. In singledipole cases with SNRs of 101 and more, the location of the true dipole was successfully estimated for about 80% of the simulations. The reconstruction with multiple linear regression corrected the location of the maximum current density estimated by the proposed spatial filtering. The dipole on the correct position contributes to more than 70% of the total dipoles in the estimated current distribution in those cases. These results show that the current distribution is effectively localized by SFR. We also investigate the differences among SFR, the LCMV (linearly constrained minimum variance) beamformer and the SAM (synthetic aperture magnetometry), the representatives of spatial filters in MEG analyses. It is indicated that spatial resolution is improved by avoiding dependence on temporal information. key words: spatial filter, multiple linear regression, Cp statistic, inverse problem, magnetoencephalography